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首先1、肿瘤是个复杂系统性的病?
1 h0 T6 i. ], H4 w4 Z4 y其次2、这就难怪为何会有如此多的肿瘤假说模型能立一家之言,其必有接近真理的一面,但太局限0 d. D/ g. s4 p- L' `* {
It is possible that the number of different tumor types is equal to the number of patients. ( a2 C" q u: }0 x
! H8 s% N6 [6 C- T4 ~' W& i, N再次3、反应了肿瘤是个需要通盘考虑的、不能仅仅局限于点、线(癌基因、肿瘤干细胞、多倍体)上的考虑、是否能集众家之长?剔伪存真 3 ?9 O) x! F$ W7 F8 R& r
the cancer stem cell theory is just playing with concept. Cancer is due to the failure of developmental (proliferation) control. The key is the mutation of genes, and epigenetic maintenance. b/ @5 Z4 ^1 U, @: J2 C
4 n; `2 @9 g4 i; t4、繁琐复杂现象的背后、必有其本质;不要急于求解现象本身,更应该追溯其本质;如果你抓住的是本质,应该适用于所有的肿瘤和解释所有现象,有本及末,方有头绪。) ?+ Y0 X5 M7 T* g9 S
5、你可能会发现,肿瘤可能比人预想的要复杂的多得多!
, N& W/ ^% w2 @5 A) M3 lI believe that we already understand at least 50% of the mystery. we just don't know how to rationally design drugs like gleevec. |
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