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首先1、肿瘤是个复杂系统性的病?$ V# ], m9 S. Q! F* c6 P
其次2、这就难怪为何会有如此多的肿瘤假说模型能立一家之言,其必有接近真理的一面,但太局限
8 c- N* x4 s* YIt is possible that the number of different tumor types is equal to the number of patients.
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9 ]7 m0 d6 E" h9 r, a& n. |, S再次3、反应了肿瘤是个需要通盘考虑的、不能仅仅局限于点、线(癌基因、肿瘤干细胞、多倍体)上的考虑、是否能集众家之长?剔伪存真
1 o' t6 A1 V6 H7 K9 |. d+ ^! L1 j1 Cthe cancer stem cell theory is just playing with concept. Cancer is due to the failure of developmental (proliferation) control. The key is the mutation of genes, and epigenetic maintenance. ; S4 d$ y9 k/ Y! {9 {
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4、繁琐复杂现象的背后、必有其本质;不要急于求解现象本身,更应该追溯其本质;如果你抓住的是本质,应该适用于所有的肿瘤和解释所有现象,有本及末,方有头绪。
" |0 N b% P8 j$ x, k5、你可能会发现,肿瘤可能比人预想的要复杂的多得多!
6 G& u t; \) c4 ?1 D- bI believe that we already understand at least 50% of the mystery. we just don't know how to rationally design drugs like gleevec. |
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