干细胞和肿瘤很相像，they can self-renew, differentiate to produce progenitors. ! L4 Z/ C9 O4 |& Vaged stem cell has reduced ability to self-renew. but cancer stem cell seems never age!
首先1、肿瘤是个复杂系统性的病？: N; c! k; e# V/ k$ ?
其次2、这就难怪为何会有如此多的肿瘤假说模型能立一家之言，其必有接近真理的一面，但太局限0 l. W, ?- C& I3 E
It is possible that the number of different tumor types is equal to the number of patients. 8 n$ T& d6 `7 x& |$ e0 G 2 p+ @; H) H/ j! C再次3、反应了肿瘤是个需要通盘考虑的、不能仅仅局限于点、线（癌基因、肿瘤干细胞、多倍体）上的考虑、是否能集众家之长？剔伪存真 ; X, E: H6 J! n' Q+ W" Uthe cancer stem cell theory is just playing with concept. Cancer is due to the failure of developmental (proliferation) control. The key is the mutation of genes, and epigenetic maintenance. 8 C' O$ ~! I( `0 }; \: s* u# }3 ?. v3 L- i0 i6 O
4、繁琐复杂现象的背后、必有其本质；不要急于求解现象本身，更应该追溯其本质；如果你抓住的是本质，应该适用于所有的肿瘤和解释所有现象，有本及末，方有头绪。0 ^# i- c( z$ J3 B5 A; ~# w o
5、你可能会发现，肿瘤可能比人预想的要复杂的多得多！ . Q! M X5 ]( cI believe that we already understand at least 50% of the mystery. we just don't know how to rationally design drugs like gleevec.
It is possible that the number of different tumor types is equal to the number of patients. $ k: M; y& S6 @; N# E9 i" x3 I我英语较差，不知所云，, f( ^+ {" n$ U. A0 `
the cancer stem cell theory is just playing with concept. Cancer is due to the failure of developmental (proliferation) control. The key is the mutation of genes, and epigenetic maintenance. ( j5 M' h( T, ]" ]
其实癌基因假说同其他许多假说模型都是有很多很多的纰漏和不足，都似乎在盲人摸象一般，只见局部不见整体。8 I$ w5 T9 X% { Y- i
I believe that we already understand at least 50% of the mystery. we just don't know how to rationally design drugs like gleevec.3 i8 o6 _6 `( l/ b
呵呵，这是我看到的最为自信的话了，我还可以更自信的说，我相信我们已经遇到肿瘤所有现象中的80%以上， 4 y% l% v6 U- U# F然而理解不超过20%.包括病因、遗传、免疫、本质等等都没有understand，都有太多的争议而没有结论。
发表于 2009-11-30 22:38
发表于 2009-12-1 09:33
