关于iPS的作用机制,这篇Nature Review Molecular Cell Biology的 Review是个不错的归纳:Open chromatin in pluripotency and reprogramming。作者提出了2个原则: specific factors maintain a globally* i) ]4 S# _( a
open chromatin state that is accessible for transcriptional activation; and other chromatin & D" N, k8 M" ~7 G- x2 ?, Zregulators contribute locally to the silencing of lineage-specific genes until differentiation is& Y4 J9 E) L0 h$ G
triggered.