求关于小分子在iPSCs诱导过程中的作用有关文献

genedu

各位大虾，谁手里有关于替代OCT4，SOX2，Klf4，c-Myc这四个因子以及其他诱导因子的小分子的文献？小弟拜谢了" `% A+ o4 x  N. E: }/ P
如果有哪位神人实际操作过的，请告知小分子名称及其用量。
; _, h% {- @& e# l0 O% k再次拜谢

cellbuddies

可以参考丁盛的文章，给你一个文章列表
/ q' s' s# _/ i, yGeneration of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors
, A) a0 ^7 s& p  u. m7 \$ USmall molecules that modulate embryonic stem cell fate and somatic cell reprogramming
* x* t1 w& F- P; a+ PA chemical platform for improved induction of human iPSCs-supplemental methods and data
8 R% y( C3 B) K/ h5 Z' N还有University of Cambridge的Austin Smiths
0 j  E* ~! B8 tPromotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

cellbuddies

full text

cellbuddies

MEK inhibitor PD0325901 (Sigma, 0.5 μM)
8 `# E6 L$ x; Y0 L4 \8 HALK5 inhibitor A-83-01 (Tocris Bioscience, 0.5 μM): f2 b2 `5 A& Z* S- R% E5 h9 D
GSK3β inhibitor CHIR99021 (BioVision, 3 μM)
' D4 `3 O8 ~& w挺贵的，大概5000大洋

genedu

回复 cellbuddies 的帖子- Q; P- q7 F& V9 k! j& \9 ^4 X
0 G: W) {( E8 V
真是太感谢了。临帖涕零，不知所言