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首先1、肿瘤是个复杂系统性的病?
5 j9 Q, F: g: Z. a2 F9 U7 E其次2、这就难怪为何会有如此多的肿瘤假说模型能立一家之言,其必有接近真理的一面,但太局限
: z4 L3 X; }% O; v3 SIt is possible that the number of different tumor types is equal to the number of patients. 9 ^; `! }. S3 P: A
/ a2 w; n. d# a8 e1 T再次3、反应了肿瘤是个需要通盘考虑的、不能仅仅局限于点、线(癌基因、肿瘤干细胞、多倍体)上的考虑、是否能集众家之长?剔伪存真 ; O1 U, j! h4 s
the cancer stem cell theory is just playing with concept. Cancer is due to the failure of developmental (proliferation) control. The key is the mutation of genes, and epigenetic maintenance. 9 K5 f l8 G% l: g1 T3 O$ r* F, i* J
6 c6 W2 Y' F* B4 a) Z1 }3 J/ W4、繁琐复杂现象的背后、必有其本质;不要急于求解现象本身,更应该追溯其本质;如果你抓住的是本质,应该适用于所有的肿瘤和解释所有现象,有本及末,方有头绪。# B# V! }& w8 m' I2 B
5、你可能会发现,肿瘤可能比人预想的要复杂的多得多!( L: |+ V- O4 n! ]1 [! v: E0 H P9 y
I believe that we already understand at least 50% of the mystery. we just don't know how to rationally design drugs like gleevec. |
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