老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
$ y3 `" V8 E- `5 ]! X. o0 r0 S2017-12-1 13:17* E  d: ]9 D  G. ?& K
Bioreactor in vivo would be the terminator of illness.
2 u8 o, G" `6 c* [1 Y2017-11-20 23:09
: e/ C5 w4 J0 K/ ?9 v1 S: Wrenew tech：剔除衰老（病变）细胞占位可以恢复青春。* a5 b' `8 k% z0 L
2017-10-23 12:508 Y% x# @) l/ T. R9 S+ |/ D  k2 \$ [/ m
魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。
, p' T3 y7 {2 V, ]/ f2017-9-30 10:58" T: c3 O/ P* |: n
Life 3.0——from decoding and coding to reading and writing/ d/ L8 G( z' x6 ?7 L) h. q' V
2017-9-21 22:32
5 Q/ r' h+ j1 V( {理论创新：亮明立场——先颠覆，再完善
/ O0 B1 k5 W( r! u' q2017-2-7 00:073 d4 K+ z/ m+ a. E0 `3 L+ V
干细胞第二定律：与细胞外基质共同构成多潜能；3 e+ S& n9 g: ?* C0 S6 Z% M1 }# ^$ c7 q
2017-1-3 11:14
& O/ j0 O8 ?/ B* l- O' Q2 l& H3 _干细胞第一定律：全生命周期保持增殖分化能力；4 w. J% `1 E3 }( ]
2017-1-3 11:13
3 q- E' S' x2 v2 |NgAgo——Never give A guideline operated！- I( a- w- g) z4 ~  E/ }
2016-12-1 10:09
0 L" C  n0 r" \$ K4 a. q; t表观遗传—— 一切皆可改变  一切皆有可能( [$ X& N( J. e2 ^5 u3 F: i' I
2016-8-17 23:37
; }. Q% T+ t; |- U子曰：吸血鬼疗法——养儿防病 养孙防老+ Z1 G/ X+ Z  @+ V) x% |, f
2016-5-23 12:055 w( m3 }+ i  J9 L- e( k
NgAgo——Debug tool kit for mammal cells
. V) ~4 j) t9 c4 k/ }1 y  [2016-5-9 13:09
! x: m) ^( g+ e8 r9 g8 h) q公理之外 皆需证明； 科学命题 皆可证伪。. [' U" V7 E1 v5 k  R1 S: p+ X- c, [
2016-1-2 00:20! v7 h& c, _! @: D$ s; @
低氧——破坏线粒体功能、诱发炎症、导致基因突变9 q3 u. L8 E- H
2015-12-16 20:19! W2 t  d8 s- q7 S9 s5 \
癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。
# a! O) e5 ?+ s2 l. ]7 z  F8 W# Qhcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)
' {+ ?' ~0 J9 y  w7 p: fsunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)
+ n0 x$ r4 T. R9 J2 X% e3 b9 thcoohboy: 3ks~ (12-24 16:45)
! e8 c" H8 |+ b. [2015-11-18 15:54
7 j) }3 }1 O, _1 e, D* d6 c- _抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。
1 P3 R7 Z8 K/ ^( }6 ?1 C2015-5-20 14:138 E! i+ G( h- x/ |6 r; G9 f" m
传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学4 K! g8 [  E0 A$ X! m
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
( E$ V; H  D! F! w9 `+ m3 w! L; X, bsunsong7: 方向对头，努力总会有结果的 (4-21 20:05)
- b1 a1 b8 E- J# n6 A% e2015-4-21 16:460 k+ X/ ^6 @8 a6 _8 h. u
search and research is just disassembling the creature.
4 j: Q# p  c- t% [/ [- K. V2015-4-7 17:01
  Y' q( d: ]( V9 Pselection is  the act of intelligence
/ J4 E2 F6 c8 o4 ~8 Q+ D2015-4-7 13:49
1 J% c: Z( t$ ~Genome fusion create neoplasm4 s. l4 R" T+ m3 V6 J
2015-1-20 13:10
' E. k( z5 j8 |STAP——Stupid Trick  Against Professional 
7 p$ K+ h' q0 l* K  c2015-1-1 19:29
( h1 R: |8 \; yinformation=structure=negentropy
( ]+ H/ q5 }0 W2014-7-22 17:36+ L" H0 b6 j, o# C
Natural mutation does not result in new functional genes 2 J) X# V$ c2 I. t) ]4 @
2014-7-3 14:06
, j7 \8 j; O) h5 I- tlife is wisdom creation instead of natural evolution
$ R; j1 H9 v) J  K3 H' Y2014-3-27 09:33
- Q* [. \$ l! k8 O/ A6 d% S) \( Clet us explore the source code of life !
) {5 h; M1 O' ^" W% k' y! t2014-3-11 13:11& ?8 E& {1 _6 ~# m4 J  d4 g
bio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.
& @6 p1 s: ~" }4 s  J5 W( [& B% s) B2013-10-7 23:06$ R9 Z( ~3 p$ ?1 Q& |  z: w
induced abortion would give the key for curing cancer 7 W. [8 L( \2 I; J& T& y+ o
2013-10-2 23:33) @) \6 B3 x* M  S  V' `
“key breakthrough” in molecular biology are entertainments' y: |, n. r3 R' y2 ?7 Y; E' e/ j
2013-6-16 11:509 k- D3 H( ?) f* ?. J3 P
Rules Of Living：trial-and-error exploring，survival takes the legitimacy  h% w1 o. P. r; O6 j' b% n
2013-6-16 11:27
& r; _+ o! j, LLife is a set of debuging programs
. ~; r: b  x, u% i2013-6-15 18:40
2 a& y9 T/ d: r! s* Jcurrent biology is closed，destined and agnostic，it is  the only contribution is to kill cells
0 R5 i6 B) ?4 a% V% Q2013-5-2 08:54
+ h6 t. x6 O1 qinformation，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
( k8 X+ l0 Y- ]0 W6 e" a9 x2013-5-2 00:516 A1 y/ t$ H; N+ s$ i
virus is the messager of  the universal life network
# t0 u$ d1 z1 e: ?4 y) s; a2013-4-18 14:33% s6 v. ~* ~9 `  f. c3 V
Genetic information doesn't improve cancer risk prediction
% f$ t! H7 L5 G/ m+ y2013-4-1 09:208 T' |% H: {7 D! C
There is no early diagnosis of cancer，but early prevention of it( }& o+ j# \4 Y# I- d7 D3 s
2013-3-27 09:17  U: E7 U! q  i. p5 L! w$ R" k1 @4 q0 a
hypoxia maintains stemness or carcinogenicity
0 r0 \/ J2 _1 u& a( u, V6 O. s2013-1-2 05:216 ~, c: U' ~8 @
cancer is the living fossil records on origin and evolution of human being$ ^3 j1 ]+ `" F6 ~. E. K
2012-12-9 23:311 }# x8 d4 ?3 l+ P
information island results cancer: W8 q; s, o" Y" M' G7 K/ ~9 ^7 y, R
2012-12-9 05:23
; o* k5 G/ b: q1 j! B" xlife is digital game
+ h+ C9 H  p8 k2012-11-10 00:17
% _( h! s1 i) z5 g1 L4 }cancer ——severe abstinence reaction of cells to niche addiction" [9 V( p. [8 m/ H
2012-9-28 12:11
; l2 \4 g+ c, y2 v; x# j  k6 X未来生物学终将回归物理(熵)及数学(分形)的美感
; N& G5 Y! P# H4 I# obiomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)
9 I" L: f7 d5 i, |' T0 `2012-9-25 21:22( F8 `, H4 C5 x/ [: ?" ~: q8 q
membrane holds the key to life" u% s/ B4 \! {6 U: ^5 q. s" }5 C
2012-8-19 20:24
( ?) p$ t/ H$ `& D) FCancer is the default state of cells
( }3 H4 E4 _8 B- w/ u  K2012-6-26 22:17
; ~! K; u5 n) t: X, ?mainstream cancer theories could be overthrown！) \3 B' f3 K5 J8 q
2012-6-25 15:43
9 }4 D' G+ k# r1 u. y* M* q; Gcarcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming...
0 O" P& j- ^3 D# t+ h6 Y2012-6-7 09:36* x- O& j8 K% l% x
every living organism connected with the water， one cell one world! @4 S3 w- C" H6 o; l
2012-4-19 22:06' U' f6 x  y$ C
chemical structure of cancer cell determines it's biological function...' {9 |/ R" f" ~  L& i. B3 a8 _  B
2012-4-7 17:56
$ x& N& m9 |) O- ^: I; QMann tracht und Gott lacht
$ U' _+ W, g& q+ k2012-3-24 21:34- E& c9 U% g2 Q% M) Y
Darwinism or genetic determinism is a fairy tale！
% L3 k6 P4 [4 `0 R2012-3-13 15:18' N# t. \6 S5 S- g# b
niche isolation is essential for cancer speciation6 C3 x3 d; q+ S, L( I& Q0 Q2 S' @
2012-3-12 12:07
) @: H3 S" ^8 }( S! f5 mHybridization Creates New Species，Mutation results species extinction9 Q% @9 j. G2 j3 i
2012-3-11 18:21  f& N$ X! @  o$ \) n- Z: W, V/ T
ROCK may join the niche reprogramming...
7 Q  B* I6 d3 j! g0 Ayuhaoze: 这是篇文献吗？ (3-9 10:41); h; C4 T/ n' A2 ^! V$ y
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)
1 `% x. v, x$ H1 s% wyuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)8 q# D4 ^, i2 i* y
2012-1-19 10:52( x/ _7 \% |/ w' P2 X9 p3 \: t
oncogenes are pseudoscience
( G1 M- Y/ [% Y! s% A3 v- Z2 Z8 L2 p+ ?2011-12-29 13:55% U# b2 s5 A2 P
gene mutation leads to variation or extinction, not new species
3 Q. i- l" Z, T/ g# L) Y2011-12-29 13:28, `7 |; P/ Q( K! p- R1 J" W
oncogenesis is non-Darwinian event: w0 s; ?) x4 W7 m  o7 N# a
2011-12-28 22:56
- Z1 j; M  j: @. s3 ldisorganization activate neurogenesis activate oncogenesis   
% B2 X" Z& n( Z) ~8 ~2011-12-22 23:38
! K  A9 }6 R/ l, b; U+ CMSC is cell feeder，tissue scaffold，immune firewall and biological glue
; t. o, O7 R; J* z- C: L6 Q) f2011-12-19 19:46& y7 `7 H, f  L. D
cancer is Noah's Ark（species carrier and life explorer）
0 \* W# U8 [9 s: |0 s) y6 a2011-12-10 09:46+ V2 j* v4 P5 @  T' N8 M  Y0 s$ V
cell fusion create new species, gene mutation induce variation
$ V2 k$ L9 E  T- }3 J1 s' ~2011-12-10 09:366 X" c. ?$ q: k8 Z
GVT will be cancer terminator， Cytokine storm will be cancer preventor
/ }( ?/ ]; y7 J' Z) p0 N2011-12-8 12:56
) M! K6 k4 o8 K+ `* o; Ocell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;
1 s6 b7 B6 a' G; W' {2011-11-27 14:54: H1 T% B: K& j. n0 Y1 Y& [
Cancer is between protozoa and mesozoa， not metazoa...' l. v2 b& ]% a
2011-11-27 00:25
  ^5 J0 \" y0 ^/ J' kcancer is neurological disease！ haha，I got it！
; r6 ^, @$ c1 D8 P2011-11-22 22:067 p; a2 z# u' m$ _  }" P$ [5 G
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
+ n6 \; a  M# P8 O2011-11-12 11:272 e4 K+ t5 t; f
cancer is the ecological invasion of hacker...
: T, j0 T0 ]$ D& }- z2011-10-5 10:31$ C! W+ }$ z, d1 H- J9 Y. j& v1 h& g
microRNA is  negentropy？
$ D# E5 a5 W7 {& I3 \2011-9-24 00:48
3 }: B$ i2 d; a/ j3 e2 X% i7 d. `cancer is the social problem  L& f; T) Q$ F# _0 E5 d3 l; j+ v
2011-9-9 23:33
- @8 N7 T" o' ~! uScience is the games of nobleman or madman; I# ?' B" {2 V# W+ E: ]/ {
2011-9-2 15:03& Y& u* u; Z, r
cancer resulted from disturbance of biological liquid crystalline state of ECM
, ?& g* E2 X6 p& `; }8 Y/ S2011-9-1 20:13
) ~8 b# ^. v* Wniche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences...
4 _1 ?  g9 k5 i& W1 _: f2011-8-13 00:37% t' j% A7 c) C( A. s$ v9 ~, v- `
Second recession is coming？, h; t* C. c, I7 ?/ o0 Z7 G
2011-8-9 23:58
1 Q4 ]7 J& K+ ^& f3 @  Y2 M  zcancer may be from sexual reproduction of somatic cells.
; |4 f! g7 P: M# T  g4 G2011-8-7 00:16
( }* t$ Y% m9 `, j9 M3 kwho determine gene？ genetic determinism is fatalism！2 G( Y' b/ A6 n, ]- H
2011-7-30 11:26: B7 P4 D) C) I* n. a) c9 x0 @0 x, }
niche reprogrammabllity is the key of solving cancer problems...: W" B5 V' H& Y# G4 s
songtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)) d: w. G$ T) f" g  X2 B. |2 A3 M  \$ b
sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54). @8 m( |! @4 {* _, F9 X
2011-7-24 01:24& G+ Y" s' s1 r' f. Q; X( J) k
cancer results from acquired genetics alterations.
, r" c' A( G8 x# F! P- t1 s: b2011-7-20 21:37
  {/ L4 w* j+ ?6 @: K) FCSCs are the low differentiated cancer cells in G0
3 f; t5 q: W" M9 {- b3 a& V2011-6-29 16:30
' ~+ Y  u+ s0 C! `iPS future——in vivo direct reprogramming ...
$ G( m3 D6 ?, d2011-5-31 15:20
0 k7 W+ w# c  z# @$ Nniche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html
3 b" D9 T* z/ @. Y! A2011-5-31 01:28
; d* c8 K- k: y9 ?+ [% b* Mall the somatic cells of Mammals are totipotent ！* V$ ~& T0 s- A% `) {
2011-5-22 22:22; |- G7 p! {7 ^  E, b
miRNA——The manipulator of  cell fate！0 m5 d2 X8 I2 K: i0 F
2011-5-20 20:21) n  I7 _4 d6 a) k
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？
8 w0 F# v! M1 f' \+ H7 E! A2011-5-17 12:38
3 t% s7 Q2 b, Q$ ^cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！  l: g9 I1 J8 E: z9 G! ?4 m, |6 d, x
2011-5-11 12:31
% @$ l4 F3 i- t7 a4 O; N. {# [cancer results from cell dedifferentiation...
# o& Q: G( G. B. s4 l4 d7 R4 w2011-4-28 18:072 h, \+ [! z" ~5 O5 `
differentiation——asymmetric cell division ！/ H4 w; F8 L' S- O& ]
2011-4-28 18:04
: v, m: V& \9 Rcancer origins from the regenerative cells！* Z$ g9 N5 n' k
2011-4-28 17:52
; z: W8 P& w9 k6 J$ n) GProliferation is differentiation potentiality！
3 b1 `% q' b/ @( K2011-4-28 17:49% {+ w- g% k3 @9 p# X+ H2 O
iPS——the key of Pandora box！
) ]; G2 \  d! E6 g& ]" J2011-4-27 22:361 e/ T* }& Z4 h
Aristotle— "The whole is greater than the sum of its parts."# O4 ~: U. Z* M# S( z/ j
2011-4-27 00:20
) u' t4 }# X' f" L: j# i1 @  Ycancer——atavistic cells
, L1 i: O; i- f. m1 I2011-4-20 00:20
+ v. g  Z0 y. B' Acancer——cellular atavism！5 |$ ?2 ^+ p0 d4 _  X
2011-4-20 00:18% L6 Z, H$ U9 D! u; E( z* V
cancer——evolutionary ancestors of mammals.9 K$ X+ b5 _' n- ~8 W
2011-4-20 00:095 B: Y7 ]6 s5 ?: R
肿瘤是细胞自组织缺陷的产物 
' K/ j5 o& z7 D$ J6 K- `2011-4-17 01:41
5 S. f4 Y# s) V7 @1 X9 c/ l! f7 ucancer——Metazoa 1.0
# z0 M- @8 {9 B! j9 W2011-4-17 01:00
9 l9 u; x+ v5 @* `, lUS——the Axis of Evil！8 g' p/ i6 L; W: e
2011-4-4 01:19" S8 J$ s# a, X; b/ ]# T' Q
美国是世界的邪恶轴心！9 N3 v1 [# J& v0 Z, A8 K: \
sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)
# }3 k' Q) s6 d2011-3-22 19:067 _, z+ i5 y" l9 M, Z" `8 G0 J
teratoma is derived from endogenous iPS！
& p1 x7 H, k9 e2 M' i2011-3-15 21:44
; g# S9 O3 `! p6 F9 f. h2 tips is a luxury gambol on  ; ~( C8 m6 Z+ Q5 R( R: X
2011-3-3 14:50
/ |- |; D7 }: k7 |cancer is intermediate of species evolution6 ^# c9 i2 K  t
2011-2-12 12:29
4 T& t/ J" Q; t) `stem cell now is on the eve of coming medical revolution0 k( k# W( }1 T1 ]$ S: I
2011-2-12 11:20
4 B# \' i4 {/ Q' BInflamation is the reprogramming process of somatic cell in vivo！
4 p. _; L- ?1 S2 v" ~2011-1-31 14:493 @$ O# h7 }% f- o, {
so-called medicine is niche regulator！
7 ?1 m. Z& f2 Q. Y- E, m& r* ]3 h2011-1-23 21:45
3 g# D* ?- l  m. S5 w. P% v7 Q! @+ bendogenous iPS is the cancer initiating cell！
. Z& U# n+ R# }6 I( L2011-1-17 16:47
# }& S& O) d5 ycancer is unicellular organisms！
8 b7 M6 y+ _; |4 ~. z1 l2011-1-9 22:04
& o0 S) M. q8 p" X# |7 dPandorabox Has Been Opened/ u4 S9 a% [. I) V
2011-1-7 23:24
  T8 Z% O$ D/ O; ~' \iPS is the Emperor's New Suit ! 
" P+ q( |& f+ H! T. X2011-1-5 23:50: P$ G$ \* w( f& q+ R. d5 y+ D3 |8 l
cell-free is the final solution of stem cell therapy
3 N9 U& G4 @3 ]7 O2011-1-5 21:46
; E* v' U9 X* ~+ e* j6 X# t0 S5 }niche is telling the story of stem cell...
/ M+ h6 ?8 T9 @+ z' `2010-12-29 17:32" T( W' _+ n+ U# R
cancer results from reprogramming of somatic cells) G% R! v- Q) C
2010-12-25 18:56
+ V2 f8 b  F# fcancer——good cells in bad niche！( E: @9 T" k' B/ ~& B3 G
2010-12-25 16:020 G+ a+ l- r0 H  V# v! T5 S/ k
cancer无罪——制造产生罪犯的土壤才是真正的犯罪！/ L5 f+ g& I$ {% V  b' R
deron: 灰常同意，有相关文献么？ (12-19 09:41)( r5 J7 ]. ?" u# k, o' Z/ e" N4 I  I
sunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)
0 R$ h, n! H& Isunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29), j; |$ }5 Q* C. ?, _$ C
2010-12-18 15:549 s* v* s: @  K' z  f
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！2 z7 j. i: D0 i
2010-12-15 15:07, X9 n( ?( a, j( q$ j& V7 Z5 w
老狼的记忆——大洪水/ E$ `) v+ f& J5 |/ V
2010-12-13 23:254 k9 w) a& c6 J8 \( z( j  j9 s
can cancer randomly differentiate into norml cell in vivo  + C4 d. x  T: V+ b# k! P
2010-12-13 22:33% E7 A3 @* U' ?
omnis cellula e cellula
: s3 i+ H/ Q' f6 |2010-12-12 09:28* L8 N& D" G6 u6 \" b" n/ `4 ^$ Q
Stem Cell ——The Origin of Disease9 F! V9 E; Y1 C8 R& I/ d
2010-12-12 09:27
& S. ]4 b& L6 p) a/ b

sun_happone

这个必须赞