关于iPS的作用机制,这篇Nature Review Molecular Cell Biology的 Review是个不错的归纳:Open chromatin in pluripotency and reprogramming。作者提出了2个原则: specific factors maintain a globally/ O- Q5 B4 x4 i; K9 T6 R+ E
open chromatin state that is accessible for transcriptional activation; and other chromatin1 z% e- g% T6 g3 H. i4 n9 Y
regulators contribute locally to the silencing of lineage-specific genes until differentiation is7 C) C- H: ^# R7 m' v* s
triggered.