求助nature Review一篇文章

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Nat Rev Mol Cell Biol. 2008 Jan;9(1):82-8./ z0 E6 q' d/ ?$ x$ a3 F  P2 o
Epidermal homeostasis: do committed progenitors work while stem cells sleep?
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3 d6 N# l) H% V2 N0 @3 GPhilip Jones is at the MRC Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge, CB2 2XZ, UK. phj20@hutchison-mrc.cam.ac.uk
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9 c: J9 q* v  F& \% pAbstract
: e2 K! a" ?6 u1 i9 xTracking the fate of cells in murine epidermis in vivo has revealed that a committed progenitor cell population can maintain normal adult tissue in the long term without support from a long-lived, self-renewing population of stem cells. Here, we argue that these results challenge the dogma that stem-cell proliferation is required for the cellular homeostasis of the epidermis and other adult tissues, with important implications for tissue physiology and disease.
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http://www.ncbi.nlm.nih.gov/pubmed?term=Epidermal%20homeostasis%3A%20do%20committed%20progenitors%20work%20while%20stem%20cells%20sleep%3F%20

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