- 积分
- 635
- 威望
- 635
- 包包
- 192
|
http://www.jci.org/articles/view/64095
/ U, X7 \2 s$ ^7 W; Y
7 k9 V5 t3 V/ zThe role of aging upon β cell turnover
# b) ^0 `4 h& S2 \ M, T W- R( t" K- t9 I6 B, U
Jake A. Kushner
, O1 r' c2 _9 }6 M3 `: S
5 E/ p- B& D* J$ x) }+ rPublished March 1, 20138 s% }: s: ^; M
2 ^* F7 i: H3 [9 s
Preservation and regeneration of β cell endocrine function is a long-sought goal in diabetes research. Defective insulin secretion from β cells underlies both type 1 and type 2 diabetes, thus fueling considerable interest in molecules capable of rebuilding β cell secretion capacity. Though early work in rodents suggested that regeneration might be possible, recent studies have revealed that aging powerfully restricts cell cycle entry of β cells, which may limit regeneration capacity. Consequently, aging has emerged as an enigmatic challenge that might limit β cell regeneration therapies. This Review summarizes recent data regarding the role of aging in β cell regeneration and proposes models explaining these phenomena. |
|